Sorbitol → Tamsulosin

HRID 77254

반응식

HRID 77254 반응식
[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH2:12][NH:13][C@@H:14]([CH2:16][C:17]1[CH:18]=[CH:19][C:20]([O:27][CH3:28])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1)[CH3:15].Cl.OC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O>>[CH3:1][CH2:2][O:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH2:12][NH:13][C@@H:14]([CH2:16][C:17]1[CH:18]=[CH:19][C:20]([O:27][CH3:28])=[C:21]([S:23]([NH2:26])(=[O:25])=[O:24])[CH:22]=1)[CH3:15]

참가 물질

3

반응물 2

HCID 5780SorbitolHCID 5362376Tamsulosin Hydrochloride

생성물 1

HCID 129211Tamsulosin

실험 절차

An amount of 36.3 mg Tamsulosin hydrochloride was added at 60° C. to 50 ml of aqueous solution containing 1.5 g of sodium alginate (Protanal LF, FMC Biopolymer) and 350 mg of sorbitol. The resulting solution was cast on two 9 cm-diameter polyester Petri dishes and dried at ambient temperature under constant airflow in a chemical hood. The dried film was tested for oral disintegration acceptance (taste, adhesion and disintegration rate). The film was found to have slight bitter taste, to have good adhesion to roof of the mouth, and oral cavity disintegration of less then one minute.

후처리

  1. customdried at ambient temperature under constant airflow in a chemical hood
  2. customone minute

출처 및 근거

ORD 기록
ord-c9f14c7c0b48445382f19a3e7f472edc
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08840935B2

연결된 노트

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