기본 정보
- 표준 SMILES
CCOc1ccccc1OCCN[C@H](C)Cc1ccc(OC)c(S(N)(=O)=O)c1.Cl- InChIKey
ZZIZZTHXZRDOFM-XFULWGLBSA-N- 분자식
- C20H29ClN2O5S
- 평균 분자량
- 445 g/mol
- 단동위원소 질량
- 444.14857071
개요
Tamsulosin hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of tamulosin and hydrogen chloride. It has a role as an antineoplastic agent and an alpha-adrenergic antagonist. It contains a tamsulosin(1+). It is an enantiomer of an ent-tamsulosin hydrochloride.
이름 및 식별자
- 우선 이름
- Tamsulosin Hydrochloride
- IUPAC
- 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxybenzenesulfonamide;hydrochloride
이름 및 동의어
TAMSULOSIN HYDROCHLORIDE106463-17-6Tamsulosin HClHarnalPradifYM617LY253351R-(-)-YM-12617DTXSID2046628Flomax MRYM-12617-1LY-253351
이름 더 보기
11SV1951MR(-)-(R)-5-(2-((2-(o-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide monohydrochlorideR-(-)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide hydrochlorideCHEBI:9399DTXCID0026628Benzenesulfonamide, 5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-, monohydrochloride, (R)-JALYN COMPONENT TAMSULOSIN HYDROCHLORIDEDiffundox
데이터베이스 식별자
- CAS
106463-17-6- PubChem CID
- 5362376
- DTXSID
DTXSID2046628- ChEMBL
CHEMBL1200914- ChEBI
CHEBI:9399- UNII
- 11SV1951MR
- EC Number
- 629-756-5
물성
구조 계산 물성
- 극성 표면적
- 108 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 7
- 회전 가능 결합 수
- 11
- 무거운 원자 수
- 29
- 형식 전하
- 0
- 복잡도
- 539
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
안전 및 규제
GHS 분류
GHS Classification
Warning
H302 (99.2%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 133 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesAcute Tox. 4 (99.2%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Tamsulosin hydrochloride
vLess-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
화학 및 산업
약리 정보
FDA Pharmacological Classification
TAMSULOSIN HYDROCHLORIDE
Adrenergic alpha-Antagonists [MoA]; alpha-Adrenergic Blocker [EPC]
MeSH Pharmacological Classification
Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.
Drugs used in the treatment of urological conditions and diseases such as URINARY INCONTINENCE and URINARY TRACT INFECTIONS.
관련 반응
6건
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