N-Isoamyl-N-(6-hydroxy naphthalene-2-sulfonyl)-D-valine tert-butyl ester → N-Isoamyl-N-(6-hydroxy naphthalene-2-sulfonyl)-D-valine

HRID 77319노트

반응식

HRID 77319 반응식
C([O:5][C:6](=[O:31])[C@@H:7]([CH:28]([CH3:30])[CH3:29])[N:8]([CH2:23][CH2:24][CH:25]([CH3:27])[CH3:26])[S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[C:17]([OH:22])[CH:18]=2)[CH:13]=1)(=[O:11])=[O:10])(C)(C)C>Cl.C(OCC)(=O)C>[CH2:23]([N:8]([S:9]([C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[C:17]([OH:22])[CH:18]=2)[CH:13]=1)(=[O:11])=[O:10])[C@@H:7]([C:6]([OH:31])=[O:5])[CH:28]([CH3:30])[CH3:29])[CH2:24][CH:25]([CH3:27])[CH3:26]

참가 물질

4

반응물 1

HCID 67155390N-Isoamyl-N-(6-hydroxy naphthalene-2-sulfonyl)-D-valine tert-butyl ester

생성물 1

HCID 67155085N-Isoamyl-N-(6-hydroxy naphthalene-2-sulfonyl)-D-valine수율 90%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 8857Ethyl Acetate용매

실험 절차

N-Isoamyl-N-(6-hydroxy naphthalene-2-sulfonyl)-D-valine tert-butyl ester (0.33 g, 0.74 mmol) is dissolved in 4 N hydrochloric acid in ethyl acetate (50 mL), and the reaction is allowed to stir at ambient temperature for 16 h. The solvent is removed in vacuo, and the residue is purified by column chromatography (15% hexanes-ethyl acetate) to afford the title compound as a colorless oil (0.26 g, 90% yield). LCMS (m/z): (394.24, M+1; 392.27, M−1).

후처리

  1. customThe solvent is removed in vacuo
  2. customthe residue is purified by column chromatography (15% hexanes-ethyl acetate)

출처 및 근거

ORD 기록
ord-a3b6b420b2a94a34aed015fcc350f7fa
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841291B2

반응 노트

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