반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:15]2[O:16][C:17]3[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=3[N:19]=2)[CH:6]=[CH:7][C:8]=1[CH2:9][N:10]1[CH:14]=[CH:13][N:12]=N1.Br[CH2:25]C1C=CC(C2OC3C=CC=CC=3N=2)=CC=1OC.N1C=CN=C1>>[N:10]1([CH2:9][C:8]2[CH:7]=[CH:6][C:5]([C:15]3[O:16][C:17]4[CH:23]=[CH:22][CH:21]=[CH:20][C:18]=4[N:19]=3)=[CH:4][C:3]=2[O:2][CH3:1])[CH:14]=[CH:13][N:12]=[CH:25]1참가 물질
4
실험 절차
Utilizing the general procedure outlined for 2-[3-methoxy-4-(1H-1,2,3-triazol-1-ylmethyl)phenyl]-1,3-benzoxazole, reaction of 2-[4-(bromomethyl)-3-methoxyphenyl]-1,3-benzoxazole (300 mg, 1.0 mmol) and imidazole (70 mg, 1.0 mmol) afforded the desired 2-[4-(1H-imidazol-1-ylmethyl)-3-methoxyphenyl]-1,3-benzoxazole as a colorless solid: 1H NMR (CDCl3, 300 MHz) δ 7.57–7.86 (m, 6H), 7.26–7.40 (m, 4H), 5.53 (s, 2H), 4.02 (s, 3H). MS (ESI) 306 (M+H)+.
출처 및 근거
- ORD 기록
- ord-06bb8c577a6e46ea8913149e21e959f7
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07087601B2
연결된 노트
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