Phosphorus oxychloride → 2-Chloro-3-iodo-5-nitropyridine

반응식

[I:1][C:2]1[C:3](O)=[N:4][CH:5]=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1.P(Cl)(Cl)([Cl:14])=O>>[Cl:14][C:3]1[C:2]([I:1])=[CH:7][C:6]([N+:8]([O-:10])=[O:9])=[CH:5][N:4]=1

참가 물질

반응물 2

HCID 24813Phosphorus oxychloride

HCID 178526840HCID 178526840, 화합물

생성물 1

HCID 111406392-Chloro-3-iodo-5-nitropyridine

실험 절차

3-Iodo-5-nitropyridin-2-ol (3.00 g, 0.0113 mol) was heated to reflux in phosphoryl chloride (15 mL, 0.1609 mol) for 4 hours. The reaction was quenched in ice/water and was neutralized with Na2CO3. The reaction was extracted with ethyl acetate and the organic extracts were washed with water, saturated NaCl, dried (MgSO4) and stripped in vacuo to give the product, which was used in the next reaction without purification.

후처리

customThe reaction was quenched in ice/water
extractionThe reaction was extracted with ethyl acetate
washthe organic extracts were washed with water, saturated NaCl
dry with materialdried (MgSO4)
customto give the product, which
customwas used in the next reaction without purification

출처 및 근거

ORD 기록: ord-4f25e1129fd24f0cb896bcefa30ff55b
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08841318B2

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