Hydrochloric Acid → 5-Chloro-2-(3-methoxy-4-pyridin-2-yl phenyl)-1,3-benzoxazole hydrochloride

HRID 7773노트

반응식

HRID 7773 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][C:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=4)=[C:12]([O:22][CH3:23])[CH:11]=3)=[N:7][C:6]=2[CH:24]=1.Cl>ClCCl.C(OCC)C>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][C:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=4)=[C:12]([O:22][CH3:23])[CH:11]=3)=[N:7][C:6]=2[CH:24]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 102866725-Chloro-2-(3-methoxy-4-pyridin-2-ylphenyl)-1,3-benzoxazole

생성물 1

HCID 219909475-Chloro-2-(3-methoxy-4-pyridin-2-yl phenyl)-1,3-benzoxazole hydrochloride

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6344Dichloromethane용매

실험 절차

5-Chloro-2-(3-methoxy-4-pyridin-2-ylphenyl)-1,3-benzoxazole (26 mg) was stirred in dichloromethane. 1.0M HCl in diethyl ether (0.95 mL) was added and allowed reaction mixture to stir for 30 minutes. Concentration of reaction mixture in vacuo gave the desired compound, 5-chloro-2-(3-methoxy-4-pyridin-2-yl phenyl)-1,3-benzoxazole hydrochloride, as a pink solid. 1H NMR (CD3OD, 300 MHz) δ 8.88–7.46 (m, 10H), 4.11 (s, 3H). MS (ESI) 337 (M+H)+.

후처리

  1. customreaction mixture
  2. customConcentration of reaction mixture in vacuo

출처 및 근거

ORD 기록
ord-d51a620251244c06bff5500e31331620
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087601B2

반응 노트

불러오는 중…