Hydrochloric Acid → (S)-4-(2-Amino-propan-1-yl)-morpholine

HRID 77757노트

반응식

HRID 77757 반응식
C(OC(=O)[NH:7][CH:8]([CH3:16])[CH2:9][N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)(C)(C)C.Cl>CO>[CH3:16][C@H:8]([NH2:7])[CH2:9][N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 15326463(1-Methyl-2-morpholin-4-yl-ethyl)-carbamic acid tert-butyl ester

생성물 1

HCID 7004115(S)-4-(2-Amino-propan-1-yl)-morpholine수율 142.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of (1-methyl-2-morpholin-4-yl-ethyl)-carbamic acid tert-butyl ester (0.30 g, 1.22 mmol) in methanol (10 mL) was added 2N HCl (5 mL) at 0° C. The reaction mixture was allowed to warm to room temperature and was stirred overnight. The solvent was removed under vacuum to give (S)-1-Methyl-2-morpholin-4-yl-ethylamine as a light yellow solid (250 mg, 96%). MS (M+H)=145.

후처리

  1. customThe solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-bbf4c539853c43e79e61d8f281056668
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841336B2

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