Hydrochloric Acid → (E)-1-(Benzyloxy)-4-(2-nitrovinyl)benzene

HRID 77793

반응식

HRID 77793 반응식
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O-].[Na+].[N+:20]([CH3:23])([O-:22])=[O:21].Cl>CO>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12](/[CH:13]=[CH:23]/[N+:20]([O-:22])=[O:21])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6375NitromethaneHCID 78109Benzaldehyde, 4-(phenylmethoxy)-HCID 10942334Sodium Methoxide2회

생성물 1

HCID 5702926(E)-1-(Benzyloxy)-4-(2-nitrovinyl)benzene수율 100%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a mixture of 4-benzyloxybenzaldehyde (1.0 g, 4.7 mmol) and sodium methoxide (28% methanol solution, 150 μL, 0.74 mmol) and methanol (10 mL) were added nitromethane (330 μL, 6.1 mmol) and sodium methoxide (28% methanol solution, 1.0 mL, 4.9 mmol) at 0° C., which was stirred for 10 minutes at room temperature. The reaction mixture was cooled to 0° C., and 5 N aqueous hydrochloric acid solution (20 mL) was added thereto at the same temperature. The reaction mixture was then stirred for 15 minutes at room temperature. The precipitated solids were filtered to obtain the title compound (1.2 g, 100%).

후처리

  1. temperatureThe reaction mixture was cooled to 0° C.
  2. stirringThe reaction mixture was then stirred for 15 minutes at room temperature
  3. filtrationThe precipitated solids were filtered

출처 및 근거

ORD 기록
ord-bdb0fc371b444c9c905b001936db5484
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841327B2

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