Carbon Tetrachloride → 1-(Chloromethyl)-4-phenoxybenzene

HRID 77872

반응식

HRID 77872 반응식
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([CH2:14]O)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Cl)(Cl)(Cl)[Cl:36]>>[Cl:36][CH2:14][C:11]1[CH:12]=[CH:13][C:8]([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:9][CH:10]=1

참가 물질

4

반응물 3

HCID 5943Carbon TetrachlorideHCID 11776TriphenylphosphineHCID 826195(4-Phenoxyphenyl)methanol

생성물 1

HCID 5209941-(Chloromethyl)-4-phenoxybenzene수율 92%

실험 절차

To a solution of (4-phenoxy-phenyl)-methanol (408 mg, 2.04 mmol) in carbon tetrachloride (8.2 mL) was added triphenylphosphine (642 mg, 2.45 mmol) under nitrogen atmosphere at room temperature, and the reaction solution was stirred under reflux for 7 hours and 40 minutes. The reaction mixture was cooled to room temperature and concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=10:1) to obtain the title compound (409 mg, 92%).

후처리

  1. temperatureunder reflux for 7 hours and 40 minutes
  2. concentrationconcentrated under a reduced pressure
  3. customThe residue was purified by silica gel column chromatography (heptane:ethyl acetate=10:1)

출처 및 근거

ORD 기록
ord-2670389cf36c4c69b06d1af2d077ee02
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841327B2

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