N1CCCC1.C(O)(=O)C.[CH3:10][O:11][C:12]1[CH:13]=[C:14]2[C:18](=[CH:19][CH:20]=1)[C:17](=O)[C:16]([CH3:27])([CH2:22][CH2:23][C:24](=[O:26])[CH3:25])[CH2:15]2>C1(C)C=CC=CC=1.CCOC(C)=O>[CH3:10][O:11][C:12]1[CH:13]=[C:14]2[C:18]([C:17]3[C:16]([CH3:27])([CH2:15]2)[CH2:22][CH2:23][C:24](=[O:26])[CH:25]=3)=[CH:19][CH:20]=1Pyrrolidine (0.159 mL, 1.9 mmol) and acetic acid (0.109 mL, 1.9 mmol) were added to a solution of 5-methoxy-2-methyl-2-(3-oxo-butyl)-1-indanone (467 mg, 1.9 mmol) in toluene (5 mL) and the resulting solution was heated in an oil bath at 85° C. for 2.5 hours. After cooling to room temperature, the reaction mixture was diluted with EtOAc (20 mL), washed with water (20 mL), 5% NaHCO3 (20 mL), and brine (10 mL), dried over MgSO4, filtered, and evaporated under vacuum to yield 7-methoxy-9a-methyl-1,2,9,9a-tetrahydro-3H-fluoren-3-one (430 mg) as a light brown solid.
불러오는 중…
