1-Bromo-3,6-dioxaheptane → 3-(2-(2-methoxyethoxy)ethyl)-5-methylthiazol-2(3H)-imine

반응식

[NH2:1][C:2]1[S:3][C:4]([CH3:7])=[CH:5][N:6]=1.Br[CH2:9][CH2:10][O:11][CH2:12][CH2:13][O:14][CH3:15]>>[CH3:15][O:14][CH2:13][CH2:12][O:11][CH2:10][CH2:9][N:6]1[CH:5]=[C:4]([CH3:7])[S:3][C:2]1=[NH:1]

참가 물질

반응물 2

HCID 1235321-Bromo-3,6-dioxaheptane

HCID 3517702-Amino-5-methylthiazole

생성물 1

HCID 668587283-(2-(2-methoxyethoxy)ethyl)-5-methylthiazol-2(3H)-imine수율 83.8%

실험 절차

A mixture of 2-amino-5-methylthiazole (1.5 g, 13.0 mmol) and 1-bromo-2-(2-methoxyethoxy)ethane (Aldrich, 2.0 mL, 14.5 mmol) was processed as in Example 157A to afford the title compound (2.2 g, 10.9 mmol, 78% yield). 1H NMR (300 MHz, CD3OD) δ ppm 2.29 (d, J=1.36 Hz, 3H) 3.34 (s, 3H) 3.49-3.54 (m, 2H) 3.60-3.66 (m, 2H) 3.80 (t, J=5.10 Hz, 2H) 4.13 (t, J=4.80 Hz, 2H) 6.99-7.04 (m, 1H); MS (DCI/NH3) m/z 217 (M+H)+.

출처 및 근거

ORD 기록: ord-69353ad9e5a04073a16d8821dfa792bb
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08841334B2

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