Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine → (R)-3-((tetrahydrofuran-2-yl)methyl)-3,4,6,7-tetrahydro-2H-pyrano[3,4-d]thiazol-2-imine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | 2H-Pyran-3(4H)-one, dihydro- | HCID 90109 | — |
| 반응물 | Potassium thiocyanate | HCID 516872 | — |
| 반응물 | (R)-(-)-Tetrahydrofurfurylamine | HCID 2734124 | — |
| 생성물 | (R)-3-((tetrahydrofuran-2-yl)methyl)-3,4,6,7-tetrahydro-2H-pyrano[3,4-d]thiazol-2-imine | HCID 68622205 | — |
반응 단계
Commercially available dihydro-2H-pyran-3(4H)-one (Small Molecules Inc), (R)-(tetrahydrofuran-2-yl)methanamine (Aldrich), potassium thiocyanate (Aldrich) and iodine (Aldrich) were processed using the method described in Example 315A to afford the title compound. LCMS (ESI+) m/z 241 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841334B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-69eff5169c93463e927402e2406d5bf8 |
| 출처 메모 | uspto-grants-2014_09 |