Water → 3-Amino-6-bromopyrazine-2-carbohydrazide

HRID 78634

반응식

HRID 78634 반응식
[NH2:1][C:2]1[C:3]([C:9]([O:11]C)=O)=[N:4][C:5]([Br:8])=[CH:6][N:7]=1.O.[NH2:14][NH2:15].O>CCO>[NH2:1][C:2]1[C:3]([C:9]([NH:14][NH2:15])=[O:11])=[N:4][C:5]([Br:8])=[CH:6][N:7]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 227251Methyl 3-Amino-6-bromopyrazine-2-carboxylate

생성물 1

HCID 580702563-Amino-6-bromopyrazine-2-carbohydrazide수율 96.3%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

Methyl 3-amino-6-bromo-pyrazine-2-carboxylate (10.18 g, 43.87 mmol) was suspended in EtOH (50.90 mL) and hydrazine hydrate (4.392 g, 4.268 mL, 87.74 mmol) was added and the reaction mixture heated at 70° C. for 2 h. Water (50 mL) was added and the precipitate isolated by filtration. The solid was washed with methanol and dried under vacuum to leave the product as a pale yellow powder (9.8 g, 96% yield); 1H NMR (400 MHz, DMSO) d 4.53 (bs s, 2H), 7.62 (br s, 2H) and 9.78 (br s, 1H) ppm; MS (ES+) 232.06

후처리

  1. customthe precipitate isolated by filtration
  2. washThe solid was washed with methanol
  3. customdried under vacuum

출처 및 근거

ORD 기록
ord-948c760558244f11ad545d61cfb4c7ff
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841308B2

연결된 노트

불러오는 중…