Water → 1-(2-Isocyanobenzyl)-3-methylurea

HRID 78684노트

반응식

HRID 78684 반응식
Cl.C([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][NH2:7])#N.[CH3:12][N:13]=[C:14]=[O:15].[CH2:16]([N:18](CC)CC)C.O>ClCCl>[N+:18]([C:4]1[CH:11]=[CH:10][CH:9]=[CH:8][C:5]=1[CH2:6][NH:7][C:14]([NH:13][CH3:12])=[O:15])#[C-:16]

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 247216502-(Aminomethyl)benzonitrile hydrochloride

생성물 1

HCID 580761271-(2-Isocyanobenzyl)-3-methylurea수율 85%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

2-cyanobenzylamine hydrochloride (90 g) and Dichloromethane (800 ml) were taken into a round bottomed (RB) flask. Methyl isocyanate (45.6 g) was added at 5° C. Triethylamine (81 g) in Dichloromethane (300 ml) was added at the same temperature and stirred at room temperature for 16 h. Water (1 L) was added and stirred for 30 min. The obtained solid was collected by filtration and dried in oven at 50° C. for 12 h. The yield is 85% and the purity 99.8%.

후처리

  1. stirringstirred for 30 min
  2. filtrationThe obtained solid was collected by filtration
  3. customdried in oven at 50° C. for 12 h

출처 및 근거

ORD 기록
ord-d44dadcd95f54f90bf9533bb53ff1bad
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841447B2

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