Ammonium Acetate → 3-(2-Fluoro-4-iodo-phenylamino)-2-methyl-isonicotinamide

반응식

[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[C:18]([CH3:19])=[N:17][CH:16]=[CH:15][C:11]=1[C:12](O)=[O:13].C([O-])(=O)C.[NH4+:24]>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[C:18]([CH3:19])=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH2:24])=[O:13]

참가 물질

반응물 2

HCID 517165Ammonium Acetate

HCID 115524733-[(2-Fluoro-4-iodophenyl)amino]-2-methyl-isonicotinic acid

생성물 1

HCID 116822133-(2-Fluoro-4-iodo-phenylamino)-2-methyl-isonicotinamide

실험 절차

3-(2-Fluoro-4-iodo-phenylamino)-2-methyl-isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.2 mmol of 3-[(2-fluoro-4-iodophenyl)amino]-2-methyl-isonicotinic acid and 0.4 mmol of ammonium acetate. LC/MS [1.85 min; 372 (M+1)].

후처리

customLC/MS [1.85 min; 372 (M+1)]

출처 및 근거

ORD 기록: ord-f29ecf7301f64e52bdf6ee760a3dd0b6
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08841459B2

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