Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Fluorophenethylamine → (2R,4S,5S)-2-benzhydryl-5-[2-(4-fluorophenyl)-ethylamino]-tetrahydropyran-4-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Fluorophenethylamine | HCID 4653 | — |
| 반응물 | (1R,4R,6S)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]-heptane | HCID 86605347 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (2R,4S,5S)-2-benzhydryl-5-[2-(4-fluorophenyl)-ethylamino]-tetrahydropyran-4-ol | HCID 11350257 | — |
반응 단계
(1R,4R,6S)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]-heptane 28c (0.02 g, 0.075 mmol) was reacted with 2-(4-fluorophenyl)-ethylamine (0.21 g, 1.50 mmol) in ethanol (Procedure E) to yield (2R,4S,5S)-2-benzhydryl-5-[2-(4-fluorophenyl)-ethylamino]-tetrahydropyran-4-ol, (+)-29c, 0.030 g (98%, [α]D=(+)63.4, c=1, MeOH).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841464B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-67d7c88ad0b64a8ea092e55a87a005fe |
| 출처 메모 | uspto-grants-2014_09 |