(4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol → 4-Chloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde

HRID 79138노트

반응식

HRID 79138 반응식
[Cl:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][N:5]=[C:4]([S:10][CH3:11])[N:3]=1>C(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[Cl:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][N:5]=[C:4]([S:10][CH3:11])[N:3]=1

참가 물질

4

반응물 1

HCID 59419388(4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol

생성물 1

HCID 594193864-Chloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde수율 82.8%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

Manganese(IV) oxide, <5 micron, activated (38.1 g, 439 mmol) was added to a solution of compound 223 (16.73 g, 87.8 mmol) in chloroform (800 mL). The reaction was stirred overnight, filtered through Celite, and the filtrate was concentrated in vacuo to yield compound 224 (13.7 g, 82.8% yield). 1H NMR (500 MHz, CDCl3) δ 10.31 (s, 1 H) 8.88 (s, 1 H) 2.65 (s, 2 H) ppm.

후처리

  1. filtrationfiltered through Celite
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-8ade62ae47844b1b97a849fa3f1c3b66
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841312B2

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