Hydrochloric Acid → HCID 178437935, 화합물

HRID 79302

반응식

HRID 79302 반응식
[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[NH:12][C:13]([C:15]2[N:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]3=[N:17][CH:16]=2)=[O:14])[N:5]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([O:31]C)[N:26]=2)[N:4]=1)[CH3:2].Cl.C([O-])(O)=O.[Na+]>C1COCC1>[CH2:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[NH:12][C:13]([C:15]2[N:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]3=[N:17][CH:16]=2)=[O:14])[N:5]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([OH:31])[N:26]=2)[N:4]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 67259608N-(3-ethyl-1-((6-methoxypyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

생성물 1

HCID 178437935HCID 178437935, 화합물수율 97.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
80 °C

실험 절차

To N-(3-ethyl-1-((6-methoxypyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide (210 mg, 0.492 mmol) in THF (6 mL) was added hydrochloric acid (4M in dioxane, 2 mL). The reaction vial was sealed, heated to 80° C. and stirred for 24 hours. The reaction was cooled to ambient temperature and saturated NaHCO3 aqueous solution was added until pH=7. THF and H2O were removed under reduced pressure. The resulting solid was washed with H2O (20 mL) and dried under vacuum to provide the desired product (198 mg).

후처리

  1. customThe reaction
  2. customvial was sealed
  3. temperatureThe reaction was cooled to ambient temperature
  4. customTHF and H2O were removed under reduced pressure
  5. washThe resulting solid was washed with H2O (20 mL)
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-c5e7b3ae1473447abe4cc9c132cd542a
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841455B2

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