Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(1-((1-(2-(tert-butyldimethylsilyloxy)ethyl)-1H-pyrazol-4-yl)methyl)-3-ethyl-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide → N-(3-ethyl-1-((1-(2-hydroxyethyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(1-((1-(2-(tert-butyldimethylsilyloxy)ethyl)-1H-pyrazol-4-yl)methyl)-3-ethyl-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide | HCID 70814928 | — |
| 촉매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | N-(3-ethyl-1-((1-(2-hydroxyethyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide | HCID 67260502 | 66.5% |
반응 단계
To N-(1-((1-(2-(tert-butyldimethylsilyloxy)ethyl)-1H-pyrazol-4-yl)methyl)-3-ethyl-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide (15 mg, 0.028 mmol) in MeOH (2 mL) was added concentrated hydrochloric acid (5 drops). The reaction was stirred for 3 hours and concentrated. Silica gel chromatography (DCM/MeOH 10:1) gave the desired product (8 mg). MS (ES+APCI) m/z=430 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08841455B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-54f2ea8e92124dda85dfc68bcc38bbd0 |
| 출처 메모 | uspto-grants-2014_09 |