HRID79315

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCc1nn(Cc2cnn(CCO[Si](C)(C)C(C)(C)C)c2)c2cccc(NC(=O)c3cnc4ccccn34)c12

HCID70814928

未命名化合物

PRODUCTS

生成物

结构：CCc1nn(Cc2cnn(CCO)c2)c2cccc(NC(=O)c3cnc4ccccn34)c12

HCID67260502

未命名化合物

收率 66.5%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID313

Hydrochloric Acid

ClH

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To N-(1-((1-(2-(tert-butyldimethylsilyloxy)ethyl)-1H-pyrazol-4-yl)methyl)-3-ethyl-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide (15 mg, 0.028 mmol) in MeOH (2 mL) was added concentrated hydrochloric acid (5 drops). The reaction was stirred for 3 hours and concentrated. Silica gel chromatography (DCM/MeOH 10:1) gave the desired product (8 mg). MS (ES+APCI) m/z=430 (M+H).

WORKUP

后处理

concentrationconcentrated