Thionyl Chloride → HCID 66937557, 화합물

HRID 79370

반응식

HRID 79370 반응식
[CH3:1][N:2]1[C:6]([CH3:7])=[CH:5][C:4]([CH2:8]O)=[N:3]1.S(Cl)([Cl:12])=O>C(Cl)Cl>[ClH:12].[Cl:12][CH2:8][C:4]1[CH:5]=[C:6]([CH3:7])[N:2]([CH3:1])[N:3]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 2776366(1,5-Dimethyl-1H-Pyrazol-3-Yl)Methanol

생성물 1

HCID 66937557HCID 66937557, 화합물수율 101.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To (1,5-dimethyl-1H-pyrazol-3-yl)methanol (5.01 g, 39.71 mmol) in DCM (80 mL) at 0° C. was cautiously added thionyl chloride (25 mL, 343.6 mmol). The cold bath was removed and the reaction mixture was stirred at ambient temperature for 3 hours. The reaction mixture was concentrated under reduced pressure to give crude product (7.32 g).

후처리

  1. customat 0° C.
  2. customThe cold bath was removed
  3. concentrationThe reaction mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a0e28097d0434a88bd9c842f43cfe4a0
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08841455B2

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