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1H-1,2,4-Triazole → N-(3-ethyl-1-((1-ethyl-1H-pyrazol-3-yl)methyl)-1H-indazol-4-yl)-7-(1H-1,2,4-triazol-1-yl)imidazo[1,2-a]pyridine-3-carboxamide

HRID 79435
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HRID 79435 반응식
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[H-].[Na+].[CH2:8]([C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][C:17]=2[NH:19][C:20]([C:22]2[N:26]3[CH:27]=[CH:28][C:29](F)=[CH:30][C:25]3=[N:24][CH:23]=2)=[O:21])[N:12]([CH2:32][C:33]2[CH:37]=[CH:36][N:35]([CH2:38][CH3:39])[N:34]=2)[N:11]=1)[CH3:9]>C1OCCOC1.CN(C)C=O>[CH2:8]([C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][C:17]=2[NH:19][C:20]([C:22]2[N:26]3[CH:27]=[CH:28][C:29]([N:1]4[CH:5]=[N:4][CH:3]=[N:2]4)=[CH:30][C:25]3=[N:24][CH:23]=2)=[O:21])[N:12]([CH2:32][C:33]2[CH:37]=[CH:36][N:35]([CH2:38][CH3:39])[N:34]=2)[N:11]=1)[CH3:9]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 92571H-1,2,4-TriazoleHCID 24758Sodium hydrideHCID 67259540N-(3-ethyl-1-((1-ethyl-1H-pyrazol-3-yl)methyl)-1H-indazol-4-yl)-7-fluoroimidazo[1,2-a]pyridine-3-carboxamide

생성물 1

HCID 67259791N-(3-ethyl-1-((1-ethyl-1H-pyrazol-3-yl)methyl)-1H-indazol-4-yl)-7-(1H-1,2,4-triazol-1-yl)imidazo[1,2-a]pyridine-3-carboxamide

시약·촉매·용매 2

HCID 6228
Dimethylformamide
용매
HCID 312751,4-Dioxane용매

실험 절차

1H-1,2,4-triazole was dissolved in 4-dioxane and treated with sodium hydride (20 mg, 0.48 mmol, 60% dispersion in mineral oil) with stirring at ambient temperature for 30 minutes. N-(3-Ethyl-1-((1-ethyl-1H-pyrazol-3-yl)methyl)-1H-indazol-4-yl)-7-fluoroimidazo[1,2-a]pyridine-3-carboxamide (35 mg, 0.08 mmol) was added as a solution in N,N-dimethylformamide. The mixture was heated to 98° C. and stirred for 2 days. The mixture was quenched by the addition of water. A precipitate formed and the solid was isolated by filtration, washed with water and dried under vacuum to give N-(3-ethyl-1-((1-ethyl-1H-pyrazol-3-yl)methyl)-1H-indazol-4-yl)-7-(1H-1,2,4-triazol-1-yl)imidazo[1,2-a]pyridine-3-carboxamide as a white solid (39 mg). MS m/z 481.1 (M+1, APCI+).

후처리

  1. temperatureThe mixture was heated to 98° C.
  2. stirringstirred for 2 days
  3. customThe mixture was quenched by the addition of water
  4. customA precipitate formed
  5. customthe solid was isolated by filtration
  6. washwashed with water
  7. customdried under vacuum

출처 및 근거

ORD 기록
ord-1f8068529cd949d78e37560e39bb2b71
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08841455B2

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