N-Boc-pyrrolidine → 2-[4-(4-{4-[2-(1-tert-butylcarbamyl-pyrrolidin-2-yl)-3-(2-trimethylsilanyl-ethoxymethyl)-3H-imidazol-4-yl]-phenyl}-2-oxo-2H-pyridin-1-yl)-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester

반응식

[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C([O:17][C:18]([N:20]1[CH2:24][CH2:23][CH2:22][CH:21]1[C:25]1[N:26]([CH2:43][O:44][CH2:45][CH2:46][Si:47]([CH3:50])([CH3:49])[CH3:48])[C:27]([C:30]2[CH:35]=[CH:34][C:33]([C:36]3[CH:41]=[CH:40][NH:39][C:38](=[O:42])[CH:37]=3)=[CH:32][CH:31]=2)=[CH:28][N:29]=1)=O)(C)(C)C.[OH-].[CH2:52]([N+](CCCC)(CCCC)CCCC)CCC.C(OC(N1CCCC1C1[NH:82][C:83]([C:86]2C=CC(B3OC(C)(C)C(C)(C)O3)=CC=2)=[CH:84]N=1)=O)(C)(C)C.C(OC(N1CCCC1[C:113]1[N:114]([CH2:119][O:120][CH2:121][CH2:122][Si:123]([CH3:126])([CH3:125])[CH3:124])[CH:115]=[C:116](Br)[N:117]=1)=O)(C)(C)C>C(O)C.[I-].C([N+](CCCC)(CCCC)CCCC)CCC.C(OCC)(=O)C.[Cu]I.CN(C=O)C.C1(C)C=CC=CC=1.C(#N)C>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:113]1[N:114]([CH2:119][O:120][CH2:121][CH2:122][Si:123]([CH3:124])([CH3:125])[CH3:126])[CH:115]=[C:116]([N:39]2[CH:40]=[CH:41][C:36]([C:33]3[CH:34]=[CH:35][C:30]([C:27]4[N:26]([CH2:43][O:44][CH2:45][CH2:46][Si:47]([CH3:48])([CH3:50])[CH3:49])[C:25]([CH:21]5[CH2:22][CH2:23][CH2:24][N:20]5[C:18](=[O:17])[NH:82][C:83]([CH3:86])([CH3:52])[CH3:84])=[N:29][CH:28]=4)=[CH:31][CH:32]=3)=[CH:37][C:38]2=[O:42])[N:117]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]