Dichloromethane → rac-(2R,3S,4R,5S)-5-(2-benzyloxycarbonyl-2-methyl-propyl)-3-(3-chloro-2-fluoro-phenyl)-4-(4-chloro-2-fluoro-phenyl)-4-cyano-pyrrolidine-2-carboxylic acid tert-butyl ester
반응식
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9]([C:10]([CH2:11][CH:12]=[N:13][CH2:14][C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])([CH3:22])[CH3:23])=[O:24].[CH2:52]1[CH2:53][CH2:54][C:55]2=[N:60][CH2:59][CH2:58][CH2:57][N:56]2[CH2:61][CH2:62]1.[CH3:45][CH2:46][N:47]([CH2:48][CH3:49])[CH2:50][CH3:51].[CH3:66][C:67]([OH:68])([CH3:69])[CH3:70].[Cl:25][c:26]1[c:27]([F:44])[c:28]([CH:32]=[C:33]([C:34]#[N:35])[c:36]2[c:37]([F:43])[cH:38][c:39]([Cl:42])[cH:40][cH:41]2)[cH:29][cH:30][cH:31]1.[Cl:63][CH2:64][Cl:65]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9]([C:10]([CH2:11][CH:12]1[NH:13][CH:14]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH:32]([c:28]2[c:27]([F:44])[c:26]([Cl:25])[cH:31][cH:30][cH:29]2)[C:33]1([C:34]#[N:35])[c:36]1[c:37]([F:43])[cH:38][c:39]([Cl:42])[cH:40][cH:41]1)([CH3:22])[CH3:23])=[O:24]
