Methanol → 1-(2-Chloro-1,1-dimethyl-ethyl)-3-(4-methyl-pyridin-3-yl)-urea

HRID 80212

반응식

HRID 80212 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH2:8].[Cl:9][CH2:10][C:11]([N:14]=[C:15]=[O:16])([CH3:13])[CH3:12].CO>C1(C)C=CC=CC=1.C(Cl)(Cl)Cl>[Cl:9][CH2:10][C:11]([NH:14][C:15]([NH:8][C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:2]=1[CH3:1])=[O:16])([CH3:13])[CH3:12]

참가 물질

6

반응물 3

HCID 887MethanolHCID 1379353-Amino-4-picolineHCID 110407471-Chloro-2-isocyanato-2-methyl-propane

생성물 1

HCID 687856051-(2-Chloro-1,1-dimethyl-ethyl)-3-(4-methyl-pyridin-3-yl)-urea수율 97.1%

시약·촉매·용매 2

HCID 1140Toluene용매HCID 6212Chloroform용매

실험 절차

4-Methyl-pyridin-3-ylamine (1.98 g, 18.33 mmol) was added to solution of 1-chloro-2-isocyanato-2-methyl-propane (3 g, 20.40 mmol) in toluene (30 mL). The resulting mixture was stirred at room temperature for 3 days. The reaction was monitored by TLC (5% MeOH in CHCl3). The reaction mixture was filtered and the residue was dried to afford 4.3 g of the product (87.75% yield).

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe residue was dried

출처 및 근거

ORD 기록
ord-5d4820338147494abd438101ec73a776
출처 데이터셋
uspto-grants-2014_09
특허 번호
USRE045173E1

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