Sodium Iodide → 4-Benzyloxy-2-fluoro-1-nitrobenzene

HRID 80519

반응식

HRID 80519 반응식
Br[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[F:9][C:10]1[CH:11]=[C:12]([OH:19])[CH:13]=[CH:14][C:15]=1[N+:16]([O-:18])=[O:17].C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>CC(C)=O>[CH2:2]([O:19][C:12]1[CH:13]=[CH:14][C:15]([N+:16]([O-:18])=[O:17])=[C:10]([F:9])[CH:11]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 5209483-Fluoro-4-nitrophenol

생성물 1

HCID 221807044-Benzyloxy-2-fluoro-1-nitrobenzene

시약·촉매·용매 1

HCID 180Acetone용매

반응 조건

온도
55 °C

실험 절차

(Bromomethyl)benzene (10.9 g, 63.7 mmol) and 3-fluoro-4-nitrophenol (10 g, 63.7 mmol) were added to 150 mL acetone followed by potassium carbonate (8.8 g, 63.7 mmol) and sodium iodide (9.54 g, 63.7 mmol). The reaction mixture was heated at 55° C. overnight. The resulting mixture was filtered and concentrated. The crude material was recrystallized in ethyl acetate/hexane to give the title compound. MS (DCI+) m/z 264.9 (M+NH4)+.

후처리

  1. filtrationThe resulting mixture was filtered
  2. concentrationconcentrated
  3. customThe crude material was recrystallized in ethyl acetate/hexane

출처 및 근거

ORD 기록
ord-9602a878ebc942c498254a3c05a59c9e
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846663B2

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