tert-butyl 2-amino-4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-7-oxo-6,7-dihydro-5H-imidazo[1,2-a][1,4]diazepin-8(9H)-yl]carbonyl}amino)propyl]benzoate → HCID 86672198, 화합물

HRID 80590노트

반응식

HRID 80590 반응식
[NH2:1][C:2]1[CH:14]=[C:13]([C@H:15]([NH:18][C:19]([N:21]2[C:27](=[O:28])[C@@H:26]([CH2:29][C:30]3[CH:35]=[C:34]([Cl:36])[CH:33]=[CH:32][C:31]=3[O:37][CH3:38])[CH2:25][N:24]3[CH:39]=[CH:40][N:41]=[C:23]3[CH2:22]2)=[O:20])[CH2:16][CH3:17])[CH:12]=[CH:11][C:3]=1[C:4]([O:6]C(C)(C)C)=[O:5]>Cl.C(O)(=O)C>[ClH:36].[NH2:1][C:2]1[CH:14]=[C:13]([C@H:15]([NH:18][C:19]([N:21]2[C:27](=[O:28])[C@@H:26]([CH2:29][C:30]3[CH:35]=[C:34]([Cl:36])[CH:33]=[CH:32][C:31]=3[O:37][CH3:38])[CH2:25][N:24]3[CH:39]=[CH:40][N:41]=[C:23]3[CH2:22]2)=[O:20])[CH2:16][CH3:17])[CH:12]=[CH:11][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

4

반응물 1

HCID 86672196tert-butyl 2-amino-4-[(1R)-1-({[(6S)-6-(5-chloro-2-methoxybenzyl)-7-oxo-6,7-dihydro-5H-imidazo[1,2-a][1,4]diazepin-8(9H)-yl]carbonyl}amino)propyl]benzoate

생성물 1

HCID 86672198HCID 86672198, 화합물

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 313Hydrochloric Acid용매

실험 절차

The compound 89b obtained at Step (2) (27.2 mg) was dissolved in a 1M hydrochloric acid in acetic acid solution, then the mixture was stirred at room temperature for 3 hours. The precipitated solid was collected by filtration to obtain the title compound (17.8 mg).

후처리

  1. filtrationThe precipitated solid was collected by filtration

출처 및 근거

ORD 기록
ord-a229a169a6f341c9b1d674310c68c966
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846660B2

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