Water → 6-Chloro-2,4-dimethylpyridazin-3(2H)-one

HRID 80949노트

반응식

HRID 80949 반응식
CI.[Cl:3][C:4]1[CH:5]=[C:6]([CH3:11])[C:7](=[O:10])[NH:8][N:9]=1.[C:12]([O-])([O-])=O.[K+].[K+].O>CN(C)C=O>[Cl:3][C:4]1[CH:5]=[C:6]([CH3:11])[C:7](=[O:10])[N:8]([CH3:12])[N:9]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 1648863(2H)-Pyridazinone, 6-chloro-4-methyl-

생성물 1

HCID 598459736-Chloro-2,4-dimethylpyridazin-3(2H)-one

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Methyl iodide (1.3 mL) was added to a mixture of 6-chloro-4-methyl-2H-pyridazin-3-one (2.70 g) and K2CO3 (3.40 g) in N,N-dimethylformamide (27 mL). The resulting mixture was stirred at ambient temperature overnight. Then, water was added and the mixture was extracted with ethyl acetate. The combined organic extracts were washed with water and brine and dried (MgSO4). After removal of the solvent, the title compound was obtained as a solid.

후처리

  1. extractionthe mixture was extracted with ethyl acetate
  2. washThe combined organic extracts were washed with water and brine
  3. dry with materialdried (MgSO4)
  4. customAfter removal of the solvent

출처 및 근거

ORD 기록
ord-661409ac12b24b6a80d7ef769018b154
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846668B2

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