Triethylamine → N-[(4-chlorophenyl)methyl]-N',N'-diethylethane-1,2-diamine

HRID 81008

반응식

HRID 81008 반응식
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[CH:4][CH:3]=1.Br.Br[CH2:12][CH2:13][N:14]([CH2:17][CH3:18])[CH2:15][CH3:16].C(N(CC)CC)C>ClCCl>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH:7][CH2:12][CH2:13][N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 660364-ChlorobenzylamineHCID 706072-Bromoethyldiethylammonium bromide

생성물 1

HCID 296048N-[(4-chlorophenyl)methyl]-N',N'-diethylethane-1,2-diamine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-Chlorobenzylamine (1.0 mL, 8.2 mmol) was added to a solution of 2-bromo-N,N-diethylethylamine hydrobromide (2.4 g, 9.0 mmol) and triethylamine (3.4 mL, 25 mmol) in dichloromethane (16 mL). The mixture was stirred at room temperature for 5 hours. The mixture was then concentrated to give N1-(4-chlorobenzyl)-N2,N2-diethylethane-1,2-diamine as an oil which was used immediately without purification.

후처리

  1. concentrationThe mixture was then concentrated

출처 및 근거

ORD 기록
ord-ea6cfcefd4a7480d8470f1ed94ea21d7
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846683B2

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