Nitroethane → 6-fluoro-5-methoxy-3-(2-nitro-propenyl)-1H-indole

HRID 8118

반응식

HRID 8118 반응식
[N+:1]([CH2:4][CH3:5])([O-:3])=[O:2].[F:6][C:7]1[CH:15]=[C:14]2[C:10]([C:11]([CH:16]=O)=[CH:12][NH:13]2)=[CH:9][C:8]=1[O:18][CH3:19].C([O-])(=O)C.[NH4+]>>[F:6][C:7]1[CH:15]=[C:14]2[C:10]([C:11]([CH:16]=[C:4]([N+:1]([O-:3])=[O:2])[CH3:5])=[CH:12][NH:13]2)=[CH:9][C:8]=1[O:18][CH3:19]

참가 물질

4

반응물 3

HCID 6587NitroethaneHCID 517165Ammonium AcetateHCID 220148046-fluoro-5-methoxy-1H-indole-3-carbaldehyde

생성물 1

HCID 695167926-fluoro-5-methoxy-3-(2-nitro-propenyl)-1H-indole수율 92%

반응 조건

온도
100 °C

실험 절차

A mixture of nitroethane(44 ml, 611 mmol), 6-fluoro-5-methoxy-1H-indole-3-carbaldehyde (11.8 g, 61 mmol), and ammonium acetate(1.78 g, 23 mmol) is stirred at 100° C. for 3 hours, allowed to cool, and is filtered to give 14 g of 6-fluoro-5-methoxy-3-(2-nitro-propenyl)-1H-indole (92%).

후처리

  1. temperatureto cool
  2. filtrationis filtered

출처 및 근거

ORD 기록
ord-a2dc7544472245ceae1897b7f180e6d7
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087635B2

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