Hydrochloric Acid → (2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidine
반응식
[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[O:4][CH2:5][C@H:6]1[CH2:10][C@H:9]([F:11])[CH2:8][N:7]1C(OC(C)(C)C)=O.Cl.C(=O)([O-])O.[Na+]>C1COCC1>[Cl:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[O:4][CH2:5][C@H:6]1[CH2:10][C@H:9]([F:11])[CH2:8][NH:7]1참가 물질
5
실험 절차
7.7 2.5 g of tert-butyl (2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidine-1-carboxylate are dissolved in 20 ml of THF and stirred at 80° C. for 2 h with 5 ml of ethanolic hydrochloric acid. After basic work-up using saturated sodium hydrogencarbonate solution, the organic phase is subjected to conventional work-up, and the residue obtained is purified by chromatography, giving 780 mg of (2R,4S)-2-(2-chlorophenoxymethyl)-4-fluoropyrrolidine as brown oil; Rt.: 0.700 min; [M+H]+230.2.
후처리
- customthe residue obtained
- customis purified by chromatography
출처 및 근거
- ORD 기록
- ord-8ec2275089e44ab09fec2df629e6515a
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08846694B2
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