Potassium tert-butoxide → 6-{[5-(2,2-diethoxyethoxy)pyridin-2-yl]oxy}-N-(5-methylpyrazin-2-yl)quinazoline-4-amine

HRID 81644

반응식

HRID 81644 반응식
[CH2:1]([O:3][CH:4]([O:14][CH2:15][CH3:16])[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10](F)=[N:11][CH:12]=1)[CH3:2].CC(C)([O-])C.[K+].[CH3:23][C:24]1[N:25]=[CH:26][C:27]([NH:30][C:31]2[C:40]3[C:35](=[CH:36][CH:37]=[C:38]([OH:41])[CH:39]=3)[N:34]=[CH:33][N:32]=2)=[N:28][CH:29]=1>CS(C)=O>[CH2:1]([O:3][CH:4]([O:14][CH2:15][CH3:16])[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([O:41][C:38]2[CH:39]=[C:40]3[C:35](=[CH:36][CH:37]=2)[N:34]=[CH:33][N:32]=[C:31]3[NH:30][C:27]2[CH:26]=[N:25][C:24]([CH3:23])=[CH:29][N:28]=2)=[N:11][CH:12]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 23665647Potassium tert-butoxideHCID 684297065-(2,2-Diethoxyethoxy)-2-fluoropyridineHCID 1356182224-((5-Methylpyrazin-2-yl)amino)quinazolin-6-ol

생성물 1

HCID 684290706-{[5-(2,2-diethoxyethoxy)pyridin-2-yl]oxy}-N-(5-methylpyrazin-2-yl)quinazoline-4-amine수율 80.1%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

반응 조건

온도
130 °C

실험 절차

5-(2,2-Diethoxyethoxy)-2-fluoropyridine (680 mg, 3.0 mmol) and potassium tert-butoxide (670 mg, 5.9 mmol) were added to a dimethyl sulfoxide solution (10 ml) of 4-[(5-methylpyrazin-2-yl)amino]quinazolin-6-ol (500 mg, 1.97 mmol), and stirred under a nitrogen atmosphere at 130° C. for 24 hours. The reaction solution was cooled to room temperature, and extracted with a mixed solution of chloroform/methanol (9:1). The organic layer was washed with aqueous saturated ammonium chloride solution and saturated saline water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (chloroform:methanol=95:5) to obtain 6-{[5-(2,2-diethoxyethoxy)pyridin-2-yl]oxy}-N-(5-methylpyrazin-2-yl)quinazoline-4-amine (730 mg, yield: 80%) as a yellow solid.

후처리

  1. temperatureThe reaction solution was cooled to room temperature
  2. extractionextracted with a mixed solution of chloroform/methanol (9:1)
  3. washThe organic layer was washed with aqueous saturated ammonium chloride solution and saturated saline water
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe obtained residue was purified by silica gel column chromatography (chloroform:methanol=95:5)

출처 및 근거

ORD 기록
ord-a31ac465982541f791cd2e29ee0d6eb2
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846700B2

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