Sodium Hydroxide → Methyl 4-(2-chloropyrimidin-4-ylthio)benzoate

HRID 81705

반응식

HRID 81705 반응식
[OH-].[Na+].[SH:3][C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1.[Cl:14][C:15]1[N:20]=[C:19](Cl)[CH:18]=[CH:17][N:16]=1>CO.O>[Cl:14][C:15]1[N:20]=[C:19]([S:3][C:4]2[CH:5]=[CH:6][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:12][CH:13]=2)[CH:18]=[CH:17][N:16]=1

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 775312,4-DichloropyrimidineHCID 237573Methyl 4-sulfanylbenzoate

생성물 1

HCID 86645567Methyl 4-(2-chloropyrimidin-4-ylthio)benzoate수율 97%

시약·촉매·용매 2

HCID 887Methanol용매3회HCID 962Water용매

실험 절차

To a sodium hydroxide (2.38 g, 59 mmol) solution in methanol (50 mL) and water (5 mL), was added dropwise a solution of methyl 4-mercaptobenzoate (9.00 g, 54 mmol) in methanol (100 mL). The mixture was stirred at room temperature for 1 hour, to this was added methanol solution (100 mL) of 2,4-dichloropyrimidine (8.77 g, 59 mmol) over 5 minutes. The whole was stirred at room temperature for 16 hours. Methanol was removed in vacuo, and the residue was partitioned between ethyl acetate (200 mL) and water (100 mL). The organic layer was separated and dried (Na2SO4). Removal of the solvent in vacuo yielded the product (14.60 g, 97%).

후처리

  1. stirringThe whole was stirred at room temperature for 16 hours
  2. customMethanol was removed in vacuo
  3. customthe residue was partitioned between ethyl acetate (200 mL) and water (100 mL)
  4. customThe organic layer was separated
  5. dry with materialdried (Na2SO4)
  6. customRemoval of the solvent in vacuo

출처 및 근거

ORD 기록
ord-83b45eba4ee148e4b7259d52a21eb72b
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846704B2

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