Benzenamine, 4-(4-morpholinyl)- → (E)-N-(3-(2-(4-morpholinophenylamino)pyrimidin-4-ylthio)phenyl)but-2-enamide

HRID 81714

반응식

HRID 81714 반응식
Cl[C:2]1[N:7]=[C:6]([S:8][C:9]2[CH:10]=[C:11]([NH:15][C:16](=[O:20])/[CH:17]=[CH:18]/[CH3:19])[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=1.[O:21]1[CH2:26][CH2:25][N:24]([C:27]2[CH:33]=[CH:32][C:30]([NH2:31])=[CH:29][CH:28]=2)[CH2:23][CH2:22]1>>[O:21]1[CH2:22][CH2:23][N:24]([C:27]2[CH:28]=[CH:29][C:30]([NH:31][C:2]3[N:7]=[C:6]([S:8][C:9]4[CH:10]=[C:11]([NH:15][C:16](=[O:20])/[CH:17]=[CH:18]/[CH3:19])[CH:12]=[CH:13][CH:14]=4)[CH:5]=[CH:4][N:3]=3)=[CH:32][CH:33]=2)[CH2:25][CH2:26]1

참가 물질

3

반응물 2

HCID 75655Benzenamine, 4-(4-morpholinyl)-HCID 86645570(E)-N-(3-(2-chloropyrimidin-4-ylthio)phenyl)but-2-enamide

생성물 1

HCID 59491799(E)-N-(3-(2-(4-morpholinophenylamino)pyrimidin-4-ylthio)phenyl)but-2-enamide수율 69.6%

실험 절차

In a procedure analogous to Example 8, reaction of (E)-N-(3-(2-chloropyrimidin-4-ylthio)phenyl)but-2-enamide (103 mg, 0.26 mmol) and 4-morpholinoaniline (47 mg, 0. 26 mmol) furnished the product (81 mg, 69%).

출처 및 근거

ORD 기록
ord-dcdee2642e314ceabf4d9cee060e0563
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846704B2

연결된 노트

불러오는 중…