Tropic acid → 3-hydroxy-2-phenyl-N-(5-{[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-3-yl)propanamide

HRID 82118

반응식

HRID 82118 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[C:18]3[CH:17]=[N:16][CH:15]=[N:14][C:13]=3[N:12]([CH:19]([CH3:21])[CH3:20])[CH:11]=2)=[O:9])[CH:5]=[N:6][CH:7]=1.[C:22](O)(=[O:32])[CH:23]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH2:24][OH:25]>>[OH:32][CH2:22][CH:23]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:24]([NH:1][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]([C:10]2[C:18]3[CH:17]=[N:16][CH:15]=[N:14][C:13]=3[N:12]([CH:19]([CH3:21])[CH3:20])[CH:11]=2)=[O:9])[CH:3]=1)=[O:25]

참가 물질

3

반응물 2

HCID 10726Tropic acidHCID 70817456(5-aminopyridin-3-yl)(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone

생성물 1

HCID 708175813-hydroxy-2-phenyl-N-(5-{[7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-3-yl)propanamide

실험 절차

The title compound was prepared according to the method described for Example 167 using (5-aminopyridin-3-yl)(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone (Preparation 95) and tropic acid to afford the title compound as a yellow solid in 7% yield, 15 mg.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-97fb3b1a234c446e9eeb928714569d02
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846698B2

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