Ethyl 4-chloroacetoacetate → Ethyl 2-(2-cyclopropyloxazol-4-yl)acetate

HRID 82209

반응식

HRID 82209 반응식
Cl[CH2:2][C:3](=O)[CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH:11]1([C:14]([NH2:16])=[O:15])[CH2:13][CH2:12]1>C1(C)C=CC=CC=1.O1CCOCC1>[CH:11]1([C:14]2[O:15][CH:2]=[C:3]([CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])[N:16]=2)[CH2:13][CH2:12]1

참가 물질

5

반응물 2

HCID 69484Ethyl 4-chloroacetoacetateHCID 80376Cyclopropanecarboxamide

생성물 1

HCID 86672106Ethyl 2-(2-cyclopropyloxazol-4-yl)acetate수율 50%

시약·촉매·용매 2

HCID 1140Toluene용매HCID 312751,4-Dioxane용매

반응 조건

온도
120 °C

실험 절차

Ethyl 4-chloroacetoacetate (20.0 g, 122.0 mmol) was added to cyclopropanecarboxamide (3.52 g, 41.5 mmol) in toluene (100 mL) and 1,4-dioxane (100 mL). The mixture was refluxed at 120° C. for 17 hours then evaporated in vacuo. The crude solid was purified by column chromatography on silica gel (80:20 petroleum ether: EtOAc) to afford the title compound as a white solid in 50% yield, 4.00 g.

후처리

  1. customthen evaporated in vacuo
  2. customThe crude solid was purified by column chromatography on silica gel (80:20 petroleum ether: EtOAc)

출처 및 근거

ORD 기록
ord-31cc3862d3244285a6a75e5c3f5b4c7c
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846698B2

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