Hydrochloric Acid → 2-(1H-indazol-6-yl)acetic acid
반응식
Cl.[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])[CH:9]=2)[CH:4]=[N:3]1>O1CCOCC1>[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:11][C:12]([OH:14])=[O:13])[CH:9]=2)[CH:4]=[N:3]1참가 물질
4
실험 절차
Hydrochloric acid (10 mL, 4 M in 1.4 dioxane) was added to tert-butyl 1H-indazol-6-ylacetate (Preparation 181, 1.00 g, 4.3 mmol) in 1,4 dioxane (5 mL) at 0° C. and the mixture was stirred at room temperature for 16 hours. The mixture was evaporated in vacuo and the residue was triturated with dry ether to afford the title compound as a white solid in 100% yield, 800 mg.
후처리
- customThe mixture was evaporated in vacuo
- customthe residue was triturated with dry ether
출처 및 근거
- ORD 기록
- ord-3c81c2c5bc02478a93749e62b6b767fe
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08846698B2
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