Hydrochloric Acid → 2-(1H-indazol-6-yl)acetic acid

HRID 82224

반응식

HRID 82224 반응식
Cl.[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:11][C:12]([O:14]C(C)(C)C)=[O:13])[CH:9]=2)[CH:4]=[N:3]1>O1CCOCC1>[NH:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:11][C:12]([OH:14])=[O:13])[CH:9]=2)[CH:4]=[N:3]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 70817797tert-Butyl 1H-indazol-6-ylacetate

생성물 1

HCID 595093302-(1H-indazol-6-yl)acetic acid수율 100%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Hydrochloric acid (10 mL, 4 M in 1.4 dioxane) was added to tert-butyl 1H-indazol-6-ylacetate (Preparation 181, 1.00 g, 4.3 mmol) in 1,4 dioxane (5 mL) at 0° C. and the mixture was stirred at room temperature for 16 hours. The mixture was evaporated in vacuo and the residue was triturated with dry ether to afford the title compound as a white solid in 100% yield, 800 mg.

후처리

  1. customThe mixture was evaporated in vacuo
  2. customthe residue was triturated with dry ether

출처 및 근거

ORD 기록
ord-3c81c2c5bc02478a93749e62b6b767fe
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846698B2

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