Ether, ethyl ethynyl → [2-Chloro-5-((E)-2-ethoxy-vinyl)-pyrimidin-4-yl]-(2-methoxy-1,1-dimethyl-ethyl)-amine

HRID 82281

반응식

HRID 82281 반응식
Br[C:2]1[C:3]([NH:9][C:10]([CH3:15])([CH3:14])[CH2:11][O:12][CH3:13])=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.[B]1OC2C(=CC=CC=2)O1.[CH2:25]([O:27][C:28]#[CH:29])[CH3:26]>>[Cl:8][C:5]1[N:4]=[C:3]([NH:9][C:10]([CH3:15])([CH3:14])[CH2:11][O:12][CH3:13])[C:2](/[CH:26]=[CH:25]/[O:27][CH2:28][CH3:29])=[CH:7][N:6]=1

참가 물질

4

반응물 3

HCID 61239Ether, ethyl ethynylHCID 6327445BenzcatechinboraneHCID 86672124(5-Bromo-2-chloro-pyrimidin-4-yl)-(2-methoxy-1,1-dimethyl-ethyl)-amine

생성물 1

HCID 86672125[2-Chloro-5-((E)-2-ethoxy-vinyl)-pyrimidin-4-yl]-(2-methoxy-1,1-dimethyl-ethyl)-amine

실험 절차

The title compound was prepared according to the method described for Preparation 61 using (5-Bromo-2-chloro-pyrimidin-4-yl)-(2-methoxy-1,1-dimethyl-ethyl)-amine (Preparation 256), catechol borane and ethoxyacetylene (40% in hexane) to afford the title compound as light brown gum in 44% yield, 2.6 g.

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-1ce22986ba4a440495b30bf3ade47f58
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846698B2

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