Hydrochloric Acid → 4-(4-Chloro-2-fluoroanilino)-7-hydroxy-6-methoxyquinoline

반응식

[CH2:2]([c:3]1[cH:4][cH:5][cH:6][cH:7][cH:8]1)[O:9][c:10]1[c:11]([O:29][CH3:30])[cH:12][c:13]2[c:14]([NH:20][c:21]3[c:22]([F:28])[cH:23][c:24]([Cl:27])[cH:25][cH:26]3)[cH:15][cH:16][n:17][c:18]2[cH:19]1.[ClH:1].[F:31][C:32]([F:33])([F:34])[C:35]([OH:36])=[O:37]>>[OH:9][c:10]1[c:11]([O:29][CH3:30])[cH:12][c:13]2[c:14]([NH:20][c:21]3[c:22]([F:28])[cH:23][c:24]([Cl:27])[cH:25][cH:26]3)[cH:15][cH:16][n:17][c:18]2[cH:19]1

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 6422Trifluoroacetic acid

HCID 22646600N-(4-chloro-2-fluorophenyl)-6-methoxy-7-phenylmethoxyquinolin-4-amine

생성물 1

HCID 1358046894-(4-Chloro-2-fluoroanilino)-7-hydroxy-6-methoxyquinoline

출처 및 근거

ORD 기록: ord-03c11cb0447640c0920aa2f2c6b7870a
출처 데이터셋: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

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