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Ammonium Hydroxide → HCID 178461168, 화합물

HRID 82346
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HRID 82346 반응식
S[C:2]1[N:3]=[C:4]([OH:12])[C:5]2[C@H:10]([CH3:11])[CH2:9][CH2:8][C:6]=2[N:7]=1.[NH4+].[OH-]>O.[Ni]>[CH3:11][C@H:10]1[C:5]2[C:4]([OH:12])=[N:3][CH:2]=[N:7][C:6]=2[CH2:8][CH2:9]1
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참가 물질

5

반응물 2

HCID 14923Ammonium HydroxideHCID 178461171HCID 178461171, 화합물

생성물 1

HCID 178461168HCID 178461168, 화합물수율 100.1%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 962Water용매

실험 절차

To a suspension of (R)-2-mercapto-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-ol (12 g, 65.8 mmol) in distilled water (100 mL) was added Raney Nickel (15 g) and NH4OH (20 mL). The mixture was refluxed for 3 hours then filtered, and the filtrate was concentrated to afford (R)-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-ol (9.89 g, 99%). MS (APCI+) [M+H]+151.

후처리

  1. temperatureThe mixture was refluxed for 3 hours
  2. filtrationthen filtered
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-9309701971a04d7a82d31fa78b347bd8
출처 데이터셋
uspto-grants-2014_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08846681B2

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