Lithium Hydroxide → HCID 67326429, 화합물

HRID 82477

반응식

HRID 82477 반응식
C[O:2][C:3](=[O:17])[C:4]([NH2:16])([C:8]([C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=[O:9])[CH:5]([CH3:7])[CH3:6].C1COCC1.[Li+].[OH-]>CO.O>[CH3:6][CH:5]([CH3:7])[C:4]([NH2:16])([C:8]([C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)=[O:9])[C:3]([OH:17])=[O:2]

참가 물질

6

반응물 3

HCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 673255273-Methyl-2-[pyridine-3-carbonyl]-amino-butyric acid methyl ester

생성물 1

HCID 67326429HCID 67326429, 화합물수율 99%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
25 °C

실험 절차

To a solution of 3-methyl-2-[pyridine-3-carbonyl]-amino-butyric acid methyl ester (1.5 g, 6.3 mmol), in methanol (15 mL), THF (9 mL) was added LiOH (1.3 g, 31.7 mmol) dissolved in water (3 mL). The mixture was allowed to stir at room temperature (25° C.) over 2 h. Solvent was evaporated from reaction mixture, dissolved in water (15 mL), acidified with 1.5N HCl extracted with ethyl acetate (150 mL), dried over sodium sulphate and concentrated to obtain product as yellow colour solid (1.38 g, 99%).

후처리

  1. customSolvent was evaporated from reaction mixture
  2. dissolutiondissolved in water (15 mL)
  3. extractionextracted with ethyl acetate (150 mL)
  4. dry with materialdried over sodium sulphate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-15fe4b8c7f4a47eca4088ce693a8f5da
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846721B2

연결된 노트

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