Nitrogen → HCID 67958123, 화합물

HRID 82838노트

반응식

HRID 82838 반응식
N#N.[Cl:3][CH2:4][C:5]1[O:6][CH:7]=[C:8]([CH2:10][OH:11])[N:9]=1.[CH3:12]I>C(Cl)Cl>[Cl:3][CH2:4][C:5]1[O:6][CH:7]=[C:8]([CH2:10][O:11][CH3:12])[N:9]=1

참가 물질

5

반응물 3

HCID 947NitrogenHCID 6328Methyl iodideHCID 67958068(2-(Chloromethyl)oxazol-4-yl)methanol

생성물 1

HCID 67958123HCID 67958123, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
40 °C

실험 절차

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of (2-(chloromethyl)oxazol-4-yl)methanol (8.00 g, 54.22 mmol) in CH2Cl2 (32.0 mL) was treated with MeI (4.05 mL, 65.06 mmol) followed by Ag2O (18.85 g, 81.32 mmol) and the resulting mixture (protected from light) was stirred overnight at 40° C. The reaction mixture was filtered and the solvent was removed under reduced pressure. Purification of the residue by FC (6:4 hept-EA) gave the title compound as a yellow oil: TLC: rf (6:4 hept-EA)=0.31. LC-MS-conditions 07: tR=0.54 min, [M+H]+=162.00.

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent was removed under reduced pressure
  3. customPurification of the residue by FC (6:4 hept-EA)

출처 및 근거

ORD 기록
ord-4b5f3d8df14e4c57b6688740bca9f124
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846733B2

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