Nitrogen → HCID 57960183, 화합물

HRID 82843노트

반응식

HRID 82843 반응식
N#N.[OH:3][CH2:4][C:5]1[O:6][CH:7]=[C:8]([C:10]([O:12][CH3:13])=[O:11])[N:9]=1.[CH3:14]I>C(Cl)Cl>[CH3:14][O:3][CH2:4][C:5]1[O:6][CH:7]=[C:8]([C:10]([O:12][CH3:13])=[O:11])[N:9]=1

참가 물질

5

반응물 3

HCID 947NitrogenHCID 6328Methyl iodideHCID 67281821Methyl 2-(hydroxymethyl)oxazole-4-carboxylate

생성물 1

HCID 57960183HCID 57960183, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
40 °C

실험 절차

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of methyl 2-(hydroxymethyl)oxazole-4-carboxylate (231 mg, 1.47 mmol) in CH2Cl2 (0.9 mL) was treated with MeI (0.11 mL, 1.76 mmol) followed by Ag2O (511 mg, 2.21 mmol) and the resulting mixture (protected from light) was stirred overnight at 40° C. The reaction mixture was filtered and the solvent was removed under reduced pressure. Purification of the residue by FC (1:1 hept-EA) gave the title compound as a colorless oil: TLC: rf (1:1 hept-EA)=0.33. LC-MS-conditions 07: tR=0.49 min, [M+H]+=172.20.

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe solvent was removed under reduced pressure
  3. customPurification of the residue by FC (1:1 hept-EA)

출처 및 근거

ORD 기록
ord-4bb216c17d44415d9ff82aa4f3b5dbd9
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846733B2

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