HCID 57467306, 화합물 → Tert-butyl [7-(aminomethyl)-1-benzyl-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate

HRID 82863노트

반응식

HRID 82863 반응식
[CH2:1]([CH:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:18]#[N:19])[CH:16]=2)[CH2:11][CH2:10][CH:9]1[NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C1COCC1.N.[Ni]>[NH2:19][CH2:18][C:15]1[CH:16]=[C:17]2[C:12]([CH2:11][CH2:10][CH:9]([NH:20][C:21](=[O:27])[O:22][C:23]([CH3:25])([CH3:24])[CH3:26])[CH:8]2[CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[CH:13][CH:14]=1

참가 물질

5

반응물 1

HCID 57467306HCID 57467306, 화합물

생성물 1

HCID 57471193Tert-butyl [7-(aminomethyl)-1-benzyl-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate수율 100.4%

시약·촉매·용매 3

HCID 935Nickel촉매HCID 222Ammonia용매HCID 8028Tetrahydrofuran용매

실험 절차

tert-Butyl 1-benzyl-7-cyano-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (1.787 g, 4.93 mmol) was dissolved in THF (40 mL) and 7 N methanolic ammonia (40 mL). Raney nickel (0.422 g, 4.93 mmol) was added. The vessel was evacuated and filled with Hydrogen at atmospheric pressure. The mixture was stirred overnight at room temperature. The catalyst was filtered off on a celite pad and washed with 500 mL MeOH. Product was obtained as a crimson powder (1.813 g, 4.95 mmol, 100%) after evaporating the solvent.

후처리

  1. customThe vessel was evacuated
  2. additionfilled with Hydrogen at atmospheric pressure
  3. filtrationThe catalyst was filtered off on a celite pad
  4. washwashed with 500 mL MeOH

출처 및 근거

ORD 기록
ord-6cf86237fda544c1a2ce561a2ddc0aac
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846741B2

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