홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Hydrochloric Acid → Methyl 2-[[[[(4-Methoxy-6-methyl-1,3,6-triazin-2-yl)amino]carbonyl]amino]sulfonyl]-1-methyl-1H-pyrrole-3-carboxylate

HRID 829
노트
인쇄 미리보기

반응식

HRID 829 반응식
[NH2:1][S:2]([C:5]1[N:6]([CH3:14])[CH:7]=[CH:8][C:9]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:4])=[O:3].C[O:16][C:17]1N=C(C)[N:20]=[C:19]([NH:24][C:25](=O)[O:26][C:27]2C=CC=CC=2)[N:18]=1.C1CCN2[C:37](=[N:38][CH2:39]CC2)CC1.Cl>C(#N)C.O>[CH3:27][O:26][C:25]1[N:24]=[C:19]([NH:18][C:17]([NH:1][S:2]([C:5]2[N:6]([CH3:14])[CH:7]=[CH:8][C:9]=2[C:10]([O:12][CH3:13])=[O:11])(=[O:4])=[O:3])=[O:16])[NH:20][N:38]([CH3:39])[CH:37]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 11448329Carbamic acid, (4-methoxy-6-methyl-1,3,5-triazin-2-yl)-, phenyl esterHCID 15790330Methyl 2-(aminosulfonyl)-1-methyl-1H-pyrrole-3-carboxylate

생성물 1

HCID 19693847Methyl 2-[[[[(4-Methoxy-6-methyl-1,3,6-triazin-2-yl)amino]carbonyl]amino]sulfonyl]-1-methyl-1H-pyrrole-3-carboxylate

시약·촉매·용매 2

HCID 962Water용매HCID 6342Acetonitrile용매

실험 절차

Methyl 2-(aminosulfonyl)-1-methyl-1H-pyrrole-3-carboxylate (0.10 g, 0.46 mmol) and 0.13 g (0.50 mmol) of phenyl (4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamate were combined in 2 mL of acetonitrile and 0.075 mL of DBU was added and the resulting amber solution was stirred at ambient temperature for 30 min. The reaction mixture was diluted with 15 mL of water and acidified with 0.5 mL 1N HCl and the resulting precipitate was collected by filtration and rinsed successively with water and ether, then dried to afford 0.13 g oil the title compound as a white solid, m.p. 189°-190° C. (dec).

후처리

  1. filtrationthe resulting precipitate was collected by filtration
  2. washrinsed successively with water and ether
  3. customdried

출처 및 근거

ORD 기록
ord-a5a19d2e3ccc4cb7bff13f06f043ffc0
출처 데이터셋
uspto-grants-1998_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05723410

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트