Hydrochloric Acid → 2-(5-Methyl-1,2,4-oxadiazol-3-yl)piperidine hydrochloride
반응식
[CH3:1][C:2]1[O:6][N:5]=[C:4]([CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][N:8]2C(OC(C)(C)C)=O)[N:3]=1.[ClH:20]>ClCCl.O1CCOCC1>[ClH:20].[CH3:1][C:2]1[O:6][N:5]=[C:4]([CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][NH:8]2)[N:3]=1참가 물질
5
실험 절차
To a cooled solution of tert-butyl 2-(5-methyl-1,2,4-oxadiazol-3-yl)piperidine-1-carboxylate (55 mg, 0.21 mmol; which may be prepared as described in Step 2) in dichloromethane (1.7 mL) was added dropwise HCl 4N in dioxane (1.3 mL). The solution was warmed to room temperature and stirred for 2 h. The solvent was evaporated under reduced pressure to give the title compound (47 mg, quantitative) as a white powder.
후처리
- customThe solvent was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-3f03f2f716724ca58cb85741166799ce
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08846711B2
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