Bromine → 2-Amino-5-bromonicotinaldehyde hydrobromide

HRID 83021

반응식

HRID 83021 반응식
[Br:1]Br.[NH2:3][C:4]1[C:9]([CH:10]=[O:11])=[CH:8][CH:7]=[CH:6][N:5]=1>C(O)(=O)C>[BrH:1].[NH2:3][C:4]1[N:5]=[CH:6][C:7]([Br:1])=[CH:8][C:9]=1[CH:10]=[O:11]

참가 물질

4

반응물 2

HCID 24408BromineHCID 7376333-Pyridinecarboxaldehyde, 2-amino-

생성물 1

HCID 866061462-Amino-5-bromonicotinaldehyde hydrobromide수율 165.3%

시약·촉매·용매 1

HCID 176Acetic Acid용매2회

실험 절차

A solution of bromine (1.05 mL, 20.0 mmol) in acetic acid (20 mL) was added to a solution of 2-amino-3-pyridinecarboxaldehyde (2.5 g, 20 mmol) in acetic acid (50 mL) at room temperature. The reaction mixture was then stirred overnight. The resulting precipitate was filtered and washed with diethyl ether to give the title compound as a white solid (4.66 g, 80%).

후처리

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with diethyl ether

출처 및 근거

ORD 기록
ord-1e3510f160a743ec895def1e08a146d2
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846711B2

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