Dichloromethane → 3-[5-(3-Methyl-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)-1,3-thiazol-2-yl]azepan-2-one

반응식

[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][N:8]2[C:9](=[O:38])[CH:10]([c:15]3[s:16][c:17](-[c:20]4[cH:21][c:22]([CH3:37])[cH:23][c:24]([NH:26][c:27]5[n:28][cH:29][cH:30][c:31]([C:33]([F:34])([F:35])[F:36])[n:32]5)[cH:25]4)[cH:18][n:19]3)[CH2:11][CH2:12][CH2:13][CH2:14]2)[cH:39][cH:40]1.[Cl:56][CH2:57][Cl:58].[OH:41][C:42]([C:43]([F:44])([F:45])[F:46])=[O:47].[OH:48][S:49]([C:50]([F:51])([F:52])[F:53])(=[O:54])=[O:55]>>[NH:8]1[C:9](=[O:38])[CH:10]([c:15]2[s:16][c:17](-[c:20]3[cH:21][c:22]([CH3:37])[cH:23][c:24]([NH:26][c:27]4[n:28][cH:29][cH:30][c:31]([C:33]([F:34])([F:35])[F:36])[n:32]4)[cH:25]3)[cH:18][n:19]2)[CH2:11][CH2:12][CH2:13][CH2:14]1