Trifluoroacetic acid → HCID 86680360, 화합물

HRID 83519노트

반응식

HRID 83519 반응식
C([O:5][C:6]([C@H:8]1[CH2:12][NH:11][C:10](=[O:13])[N:9]1[CH3:14])=[O:7])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)(Cl)Cl>[CH3:14][N:9]1[C@@H:8]([C:6]([OH:7])=[O:5])[CH2:12][NH:11][C:10]1=[O:13]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 86680358(R)-3-Methyl-2-oxoimidazolidine-4-carboxylic Acid tert-butyl Ester

생성물 1

HCID 86680360HCID 86680360, 화합물수율 76.9%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a solution of (R)-3-methyl-2-oxoimidazolidine-4-carboxylic acid tert-butyl ester (94 mg) in chloroform (2 ml) was added trifluoroacetic acid (1 ml) at room temperature, and the mixture was stirred for 3 hours. This reaction solution was concentrated under reduced pressure, additional toluene (3 ml) was added thereto, and the mixture was again concentrated. To the resulting residue was added diethyl ether (0.5 ml) at room temperature, and the mixture was stirred. Next, n-hexane (2 ml) was added thereto, and the mixture was further stirred. The insoluble substance was collected by filtration, and dried under reduced pressure to give the titled compound (52 mg).

후처리

  1. concentrationThis reaction solution was concentrated under reduced pressure, additional toluene (3 ml)
  2. additionwas added
  3. concentrationthe mixture was again concentrated
  4. additionTo the resulting residue was added diethyl ether (0.5 ml) at room temperature
  5. stirringthe mixture was stirred
  6. additionNext, n-hexane (2 ml) was added
  7. filtrationThe insoluble substance was collected by filtration
  8. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-bca779d571af4ab59a57660b8c9f29b6
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846746B2

반응 노트

불러오는 중…