4'-Hydroxyacetophenone → 2-Bromo-1-(4-hydroxyphenyl)ethanone
반응식
[Br:1]Br.[CH3:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]([OH:12])=[CH:10][CH:11]=1)=[O:5].C(=O)(O)[O-].[Na+]>CCOCC>[CH:7]1[C:6]([C:4]([CH2:3][Br:1])=[O:5])=[CH:11][CH:10]=[C:9]([OH:12])[CH:8]=1참가 물질
5
실험 절차
Bromine (17.6 g, 110 mmol) was added dropwise to a 0° C. solution of 4-hydroxyacetophenone (15 g, 110 mmol) in ether (200 mL) over 20 minutes. The mixture was stirred for 1 hour. and poured carefully into saturated sodium bicarbonate solution (500 mL). The organics were washed with saturated sodium bicarbonate solution, dried over magnesium sulfate and concentrated in vacuo. The crude product was then recrystallized from ether to afford the title compound (14.1 g).
후처리
- washThe organics were washed with saturated sodium bicarbonate solution
- dry with materialdried over magnesium sulfate
- concentrationconcentrated in vacuo
- customThe crude product was then recrystallized from ether
출처 및 근거
- ORD 기록
- ord-4e59850cfc72451ebafb7bb369e48245
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07087757B2
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